The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees

The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees

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best c4 corvette seat covers The genetic variation of the European population at a macro-geographic scale follows genetic gradients which reflect main migration events.However, less is known about factors affecting mating patterns at a micro-geographic scale.In this study we have analyzed 726,718 autosomal single nucleotide variants in 435 individuals from the catalan Pyrenees covering around 200 km of a vast and abrupt region in the north of the Iberian Peninsula, for which we have information about the geographic origin of all grand-parents and parents.

At a macro-geographic scale, our analyses recapitulate the genetic gradient observed in Spain.However, we also identified the presence of micro-population substructure among the sampled individuals.Such micro-population substructure does not correlate with geographic barriers such as the expected by the orography of the considered region, but by the bishoprics present in the covered geographic mybouddha bracelet 7 chakras area.

These results support that, on top of main human migrations, long ongoing socio-cultural factors have also shaped the genetic diversity observed at rural populations.